Kinetic modeling of hyperpolarized13C pyruvate metabolism in tumors using a measured arterial input function
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چکیده
منابع مشابه
Kinetic Modeling of Hyperpolaized [1-13C]Pyruvate Metabolism in Blood
INTRODUCTION Dynamic Nuclear Polarization (DNP) of metabolically active 13C-labelled substances has been reported as a method of generating MR images of in vivo cellular metabolism [1] and hence has the potential to detect aggressive cancers that exhibit heightened metabolism [2]. By injecting active, hyperpolarized 13C metabolites such as pyruvate, it is possible to visualize their transformat...
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15 صفحه اولKinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors.
Hyperpolarized [1-(13)C]-pyruvate has shown tremendous promise as an agent for imaging tumor metabolism with unprecedented sensitivity and specificity. Imaging hyperpolarized substrates by magnetic resonance is unlike traditional MRI because signals are highly transient and their spatial distribution varies continuously over their observable lifetime. Therefore, new imaging approaches are neede...
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Background Modern MRI myocardial perfusion protocols use rapid venous bolus injections, typically 3-5 ml/s of 5-15 ml of agent over a few seconds. The resulting arterial input functions are rapidly varying with high agent concentrations (Fig. 1A and 1B) and thus typically require high temporal resolution acquisitions (~1 sec), custom pulse sequences and complex processing methods for perfusion ...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2012
ISSN: 0740-3194
DOI: 10.1002/mrm.24546